Heatmap and correlations between IGF2BP3 and immune checkpoints including PD-L1, PD-L2, LAG3, CTLA4, and TIM3 were shown in Fig. 11A. We found significant positive correlations between the IGF2BP3 expression and PD-L1, PD-L2, LAG3, CTLA4, and TIM3 expression in bladder cancer (Fig. 11B-F). The gene discussed is LAG3; the disease is urinary bladder cancer.