The main study findings were as follows: (1) Pg correlated positively with systemic inflammation regardless of the Pg infection mode, and systemic inflammatory molecular levels increased significantly; (2) Pg positivity in the circulatory system (cfDNA and gDNA) was an independent risk factor for first-time AMI and was related to the severity of coronary artery, with a possible clinical significance for optimizing risk stratification in CHD patients; and (3) the study findings further strengthened the possibility of an independent relationship between PD and CVD manifestations. Here, JUP is linked to coronary artery disorder.