G3BP1 and gastric cancer: circIPO7 was previously shown to have a positive relationship with the prognoses of GC patients, and herein, we further discovered that overexpressed circIPO7 in GC cells could directly bind with caprin-1 and then block its recruitment to ribosomes by competing against G3BP1, thereby leading to translational inhibition of its target mRNAs, including EGFR and mTOR.