circIPO7 was previously shown to have a positive relationship with the prognoses of GC patients, and herein, we further discovered that overexpressed circIPO7 in GC cells could directly bind with caprin-1 and then block its recruitment to ribosomes by competing against G3BP1, thereby leading to translational inhibition of its target mRNAs, including EGFR and mTOR. This evidence concerns the gene EGFR and gastric cancer.