PGAM1 and PGAM2 are two tissue-specific isoforms in human, the former has been reported to be commonly upregulated in many human cancers, and was induced to play an important role in mTOR-mediated Warburg effect and tumor growth, whose abundance was an adverse predictor for patient survival in NSCLC, while the latter had no above-mentioned functions33 and its relationship with tumors was seldom reported. The gene discussed is MTOR; the disease is cancer.