PFKM and hepatocellular carcinoma: Multiple glycolytic enzymes, such as PFK1 (phosphofructokinases) and ALDOA (fructose-bisphosphate aldolase A)7,8, have been reported to be overexpressed in HCC, and some studies demonstrated that the active aerobic glycolysis phenotype was associated with poor prognosis of HCC9, meanwhile, increases of glycolytic enzymes (aldolase, enolase, and pyruvate kinase) correlated with sorafenib resistance have been previously reported in HCC patients and cells10,11.