PFKM and brain neoplasm: S667 phosphorylation of PFK1 has been annotated in UniProt website (https://www.uniprot.org/), and it was reported that phosphorylation of PFKP (another isoform of PFK1) Y64 could enhance PFK1 activation and GLUT1 expression which promoted the Warburg effect, tumor cell proliferation, and brain tumorigenesis28, and phosphorylation of PFK1 platelet isoform PFKP S386 in human glioblastoma cells could increase PFKP expression and promote aerobic glycolysis, cell proliferation, and brain tumor growth29.