In this study, phosphorylation of PFKM (one of the PFK1 isoforms) decreased for fourfold and 4.3-fold with the treatment of PZH and sora respectively, but it remains elusive of S667 phosphorylation function or if PFKM activity was down-regulated by PZH and sora through serine phosphorylation to attenuate Warburg effect and tumor growth. Here, PFKM is linked to neoplasm.