KEGG analysis revealed that pathways including protein processing in endoplasmic reticulum, glycolysis/gluconeogenesis, microRNAs in cancer, and calcium signaling pathway were significantly enriched in PZH versus control group (Fig. 7A), while pathways such as pyruvate metabolism, glyoxylate and dicarboxylate metabolism, glycolysis/gluconeogenesis, PPAR signaling pathway, calcium signaling pathway, citrate cycle, propanoate metabolism, and insulin signaling pathway were remarkably enriched in sora versus control group (Fig. 7B). The gene discussed is INS; the disease is cancer.