NFKB1 and breast cancer: Moreover, we analyzed publicly available data from metastatic breast cancer patients and found an overrepresentation of NF-κB signaling in lung, liver and bone metastases, which grow in lipid-rich environments (Figure 1a-b and 31) compared to brain metastases where CSF and interstitial fluid are lipid deprived environment 32,33 (Figure 5g).