JUP and neoplasm: Next, we applied SPHINKS to generate tumor-specific kinase–phosphosite interactomes for PG, BRCA and LSCC, including 669, 1,399 and 1,985 kinase–phosphosite relationships from 76, 198 and 103 kinases and 210, 1,899 and 699 phosphosites for PG, BRCA and LSCC, respectively and identified subtype-specific MKs (Supplementary Tables 8–10 and Extended Data Fig. 9) that we validated by global protein abundance and mRNA expression (Supplementary Tables 8–10).