VEGFA and myalgic encephalomeyelitis/chronic fatigue syndrome: VEGF-A could play a role in post-exertional malaise and fatigue experienced by ME/CFS patients because VEGF-A is known to direct vasculogenesis and angiogenesis, plays a role in the maintenance of capillary supply in normal skeletal muscle and its mRNA was shown to increase in skeletal muscles following acute exercise45,46.