Expression of ISGs (Mx1, Isg15, Isg20, Ifitm1, Bst2, and Oas1) (Fig. 9d), and immune cell markers Lyz2 and Cd68 were markedly lower in 3TC mice with FA-induced kidney injury compared to controls (Fig. S15b). This evidence concerns the gene ISG20 and Friedreich ataxia.