Similarly, we observed an increase in transcript levels of various nucleic acid sensors such as Rigi, Mda5, Lgp2, Tlr4, Tlr7, Aim2, Cgas, Sting (Fig. S3a), and activated RIG-I signaling pathway (Fig. S3b) in kidneys of two different murine CKD models. The gene discussed is AIM2; the disease is chronic kidney disease.