Nevertheless, a similar trend was observed in the cases of cytotoxic, IFNγ-expressing and IL-2-expressing CD4+ T cells as for the S1-specific plasma IgG; 2xVacc+δ, 3xVacc, 3xVacc+ο, and 3xVacc+δ were higher than the baseline 2xVacc group and the groups with an alpha breakthrough infection; 2xVacc+α, 3xVacc+α (Fig. 4b). The gene discussed is IFNG; the disease is infection.