Mining a published single-cell ATACseq dataset of TILs from cancer patients, we found an open chromatin region (OCR) 7 kbp downstream of the transcriptional start site of the SNX9 gene with increased accessibility in intermediate and late-exhausted compared to naïve, memory, effector, and early exhausted CD8 T cells (Supplementary Fig. 4a)41. This evidence concerns the gene CD8A and cancer.