Recent evidence indicated that PRDX1 could promote the degradation of NOXA, and targeting PRDX1 might be an effective strategy to overcome the resistance of colorectal cancer to DNA damage-inducing chemotherapeutics.43 While our results suggest that PRDX1 inhibition alone is sufficient to suppress the proliferation of colorectal cancer. This evidence concerns the gene PRDX1 and colorectal cancer.