ASCL1 and adenocarcinoma: ASCL1 is also an androgen-regulated gene and its loss abrogates antiandrogen-induced plasticity, suggesting that ASCL1 is required for treatment-induced plasticity32., implicating initiation of an ASCL1 clone by trans-differentiation from adenocarcinoma post antiandrogen treatment to drive NEUROD1 subclone31 and progression to NEPC.