TET2 and neoplasm: Interestingly, 5-hmC levels significantly correlate with the proportion of SP cells in tumor tissues; moreover, TET2 expression is reduced substantially in Huh7 SP cells than in non-SP cells, along with the decline of 5-hmC level, and overexpression of TET2 in Huh7 MDR cells increased 5-hmC level and reduced SP proportion.