Here, despite the expression of TET2 in HCC cells didn’t affect tumor growth in vivo when treated with vehicles, the chemo-resistant potential of Huh 7 MDR and TET2 deficient Huh7 cells was preserved, which further indicated that TET2 reduction greatly affected the chemo-resistant phenotype of HCC cells whether in vivo or in vivo. Here, TET2 is linked to hepatocellular carcinoma.