These findings were consistent with previous data showing that loss of DKC1 reduces the accumulation of a subset of H/ACA snoRNA-derived miRNAs in different cellular contexts (Alawi & Lin, 2010) and supported the possibility that down-regulation of DKC1 underlies the impoverishment of H/ACA snoRNAs in metastatic cSCC. The gene discussed is DKC1; the disease is skin squamous cell carcinoma.