Our results in metastatic cSCC parallel with those that associate the expression of the fatty acid receptor CD36 with metastasis in oral SCC metastasis-initiating cells and in experimental metastasis models of human melanoma and breast cancer (Pascual et al, 2018), and underscore the notion that the enhanced expression of specific fatty acid receptors in each tumor type is a key feature for the acquisition of metastatic traits. This evidence concerns the gene CD36 and melanoma.