Quantitative scoring of the expression of the lipid enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) in primary cSCC tumors and in metastatic samples underlined the relevance of the in vitro data and their translational potential for the clinical management of cSCC patients. The gene discussed is HMGCS1; the disease is skin squamous cell carcinoma.