This metabolic switch would directly impact on the migratory and invasive abilities of cSCC cells, specifically required in the most early metastatic step, in agreement with data reporting the association of acetyl-CoA hydrolysis with hepatocellular carcinoma (HCC) metastasis through the epigenetic regulation of TWIST2 (Lu et al, 2019), and could also explain the changes observed in cytoskeleton remodeling and the enhanced endocytic Ras-related protein Rab-5A/Rab11 trafficking in breast cancer and osteosarcoma cells with reduced DKC1 levels (Di Maio et al, 2017). This evidence concerns the gene RASD1 and osteosarcoma.