,16 For all three datasets surveyed (PDX compendium, patient tumor metastasis compendium, TCGA), one gene, APC, was consistently enriched for mutation events (p < 0.01, one-sided Fisher’s exact test) in the s1 subtype, due in part to the relative enrichment of s1 for colorectal cancers (Figure S2F). Here, APC is linked to neoplasm.