This association included annexin genes, S100A10, S100A6, PTGER1, PTGER2, PTGS2, TBXA2R, AKR1C3, and HPGD. Prostaglandin E2 (PGE2) can promote tumor growth by binding to its receptors and activating signaling pathways that control cell proliferation, migration, apoptosis, or angiogenesis.27 This evidence concerns the gene HPGD and neoplasm.