Finally, SIK3 has been demonstrated to limit endotoxemia in vivo, as intraperitoneal injection of LPS into SIK3 KO (but not SIK1 or SIK2 KO mice) animals resulted in increased mortality and serum levels of TNF-α and IL-6 (212). The gene discussed is SIK3; the disease is serum lipopolysaccharide activity.