SIK2 and Salmonella Infections: Nevertheless, a phosphoproteomic analysis of host cell responses to Salmonella infection recently picked up an entirely novel target of SIK2: HCT116 cells infected with Salmonella surprisingly showed that SIK2 directly associates with actin filaments under basal conditions but, upon Salmonella infection, is recruited to the protective Salmonella-containing vacuole with elements of the actin polymerization machinery (50).