Wein et al. (255) have shown that in vivo inhibition of SIK using a single daily dose of YKL-05-099 can mimic the effects of the parathyroid hormone on osteocytes, increasing bone formation and bone mass, thus demonstrating the potential of small molecule SIK inhibitors in the treatment of osteoporosis. The gene discussed is SIK1; the disease is osteoporosis.