Genetic studies have identified a human T2DM risk variant rs4841132 within the long non-coding RNA LOC157273 on chr8p23.1, associated with altered expression of PPP1R3B which encodes a PP1 regulatory subunit; this suggests a link between PP1 and T2DM or other metabolic traits [28,41]. This evidence concerns the gene PPP1R3B and type 2 diabetes mellitus.