IDH2 and chondrosarcoma: Three representative conventional chondrosarcoma cell lines (CH2879 [IDH wildtype], JJ012 [IDH1 mutant], and SW1353 [IDH2 mutant]) were cultured as alginate spheroids and treated with talazoparib (0.001 to 10 μM), temozolomide (0.01 to 100 μM), or combinations of these drugs for 3, 7, and 14 days, representing different stages of spheroid growth.