Multivariable analysis showed that CH-PD presence was independently associated with worse OS (HR, 1.52 [95% CI, 1.06-2.20]; P = .02) after accounting for age, prior therapies (radiotherapy and/or chemotherapy) and tumor characteristics (ERBB2 status and MSI-H) (Table 2). This evidence concerns the gene ERBB2 and neoplasm.