There was no significant difference in the proportion of the most frequently altered genes between EGC and CRC cohorts (DNMT3A [OMIM 602769], TET2 [OMIM 612839], PPM1D [OMIM 605100], ASXL1 [OMIM 612990], ROS1 [OMIM 165020], ALK [OMIM 105590], TP53 [OMIM 191170], TMPRSS2 [OMIM 602060], and ATM [OMIM 607585]) (Figure 1A-B and eTable 2 in Supplement 1). Here, DNMT3A is linked to colorectal carcinoma.