IGF1 and mastitis: Genetic variations of domestic cows like SNPs of the bovine IGF1 gene, breeding selections for lactation performance (enhanced bovine MIR148A expression), prevalence of mastitis, feeding procedures (grass versus corn), and environmental contaminations (aflatoxins, bisphenol A, pesticides, BMMFs, MPs, nanoplastics) are not and could never be taken into account by epidemiological studies, but may all have synergistic impacts on milk’s oncogenic signaling capacity (Table 1).