APP and Alzheimer disease: Thus, this chaperone shows the beneficial role on correcting protein folding and trafficking leading to the partial recovery of UPS and autophagy functionality in AD astrocytes, with effect on the immune function, as indicated by the decreased concentrations of pro inflammatory cytokines (Fig. 4) and consequent modulation of immunoproteasome (Fig. 3B) and an effect on APP processing (Fig. 6).