APP and Senile plaques: Moreover, since the discovery of high levels of ubiquitin in senile plaques, correlation between Aβ and 26S proteasome has been confirmed in cultured neurons and astrocytes [66, 67] and our data on APP, Aβ40, and Aβ42 levels in 3Tg-iAstro are in line with these studies (Fig. 6).