After the patient died, a stored blood sample was sent to the Japanese Collaborative Research Group for an Integrated Consignment Screening Test [7, 8], and detailed experimental examination of stored patient plasma collected at postoperative day 16, confirmed severe multiple coagulation factor deficiencies, including deficiencies in Factor V/5 (FV/5), Factor X/10 (FX/10), and Factor VIII/8 (FVIII/8) (Table 1). This evidence concerns the gene F5 and hyperinsulinemic hypoglycemia, familial, 4.