In this large-scale postmortem study, we showed that cortical FKBP5/FKBP51 mRNA/protein (FKBP5/1) expression levels are consistently increased in psychopathology and exacerbated with age across multiple areas of the neocortex—the dorsolateral prefrontal cortex, the orbitofrontal cortex, and the ventral anterior cingulate cortex—with strikingly higher gene and protein expression levels in individuals with schizophrenia, and depression to a lesser extent. The gene discussed is FKBP5; the disease is major depressive disorder.