Complement, C-reactive protein complex level, and number of white blood cells (markers of inflammatory reaction) are increased in patients who develop AF.81,82 Corticosteroids have anti-inflammatory activity and reduce exaggerated inflammatory reaction.83 Prospective randomized trials in nonoperative patients have reported that corticosteroid therapy reduces the risk of recurrent and permanent AF in patients converted from their first episode of AF.84 Here, CRP is linked to atrial fibrillation.