For instance, according to the Human Gene Mutation Database (www.hgmd.cf.ac.uk), nearly 400 missense mutations in the DYSF gene, responsible for the membrane repair protein dysferlin, are documented to cause weakness and deterioration in muscles of the arms and legs and manifested in multiple forms of limb-grindle muscular dystrophy (LGMD), Miyoshi myopathy, or general dysferlinopathies. The gene discussed is DYSF; the disease is limb-girdle muscular dystrophy.