Truncation and missense mutations have been observed in the repair protein AHNAK in congenital heart disease patients [44] and a missense mutation in apoptosis-linked gene 2 (ALG-2, also called programmed cell death 6 protein [PDCD6]) is observed in patients with left ventricular noncompaction [45]. The gene discussed is PDCD6; the disease is left ventricular noncompaction.