Another example is Gordon syndrome (29, 62) (also known as pseudohypoaldosteronism type II or familial hyperkalemic hypertension syndrome) (27, 31), in which a loss-of-function mutation in cullin-3 affects proteasomal degradation of the with-no-lysine (WNK) serine-threonine kinase family (WNK1 and WNK4) (28, 29, 58). Here, CUL3 is linked to Gordon syndrome.