ARG1 and familial pancreatic carcinoma: Next, to determine whether the increase in Arg1 expression was recapitulated in a mouse model of pancreatic cancer, we analyzed our mouse sc-RNA-seq data from healthy mice and tumor-bearing KPC (KrasLSL-G12D/+;p53LSL-R172H/+;Ptf1aCre/+) (Hingorani et al., 2005) mice (Figure 1F and Figure 1—figure supplement 1C and D).