(D) Genetic makeup of the KrasFrt-STOP-Frt-G12D/+;Ptf1aFlpO/+;Lyz2Cre/+;Arg1f/f (KFCA) mouse model for the deletion of Arg1 in myeloid cells during PDA tumorigenesis. Here, ARG1 is linked to Patent ductus arteriosus.