CD8A and familial pancreatic carcinoma: We and others have shown that myeloid cells promote pancreatic cancer growth both directly and by inhibiting CD8+ T cell anti-tumor immunity (Zhang et al., 2017b; Zhang et al., 2017a; Mitchem et al., 2013; Halbrook et al., 2019; Steele et al., 2016; Liou et al., 2015).