We further found that CKO of neuronal FcγRI in the DRG or Syk inhibition can attenuate CCI‐induced Syk activation and NF‐κB p65 activation in DRG neurons and decrease NLRP3, IL‐1β, and IL‐18 expression levels in DRG after neuropathic pain. Here, SYK is linked to neuropathic pain.