CRP and complex regional pain syndrome: Previous research has revealed that IVIG may be beneficial for managing neuropathic pain.[29] Some research has reported that IVIG and plasma exchange therapy could effectively improve pain symptoms in some CRPS patients.[30] FcγRI, which is the high‐affinity Fc‐gamma receptor, can bind both IgG‐IC and monomeric IgG.[11, 31] IgG1 bound to FcγRI with an affinity of 0.03 μμ, higher than CRP binding to other FcγRs. We examined the therapeutic effect of naive IgG injection in the local DRG and found persistent pain relief in CCI rats.