STAT3 and neoplasm: For example, lncRNA KLHDC7B could enhance PDAC cell proliferation and macrophage M2 polarization to activate STAT3 signals in an autocrine and paracrine manner.[39] In addition, lncRNAs are directly encapsulated into the EVs and transported into TME, which alter EMT and promote metastasis by activating downstream signaling pathways.[40] In this study, we discovered that overexpressed lnc‐FSD2‐31:1 induced tumor suppression and ensured long‐term OS after surgery in PDAC patients.