LncRNAs drive a constellation of phenotypes of cancer by acting on dysfunctional intrinsic cellular regulatory networks and intercellular communication to generate the tumor microenvironment.[38] LncRNAs can bind with targeted intracellular proteins to enhance the PDAC phenotypes.[6] Our previous study has demonstrated that MALAT1 interacts with HuR, which promotes PDAC proliferation and metastasis.[35a] Inversely, lncRNAs could also interact with proteins or miRNAs to inhibit the spread of complexes across different chromatin domains and affect different types of cells. The gene discussed is MALAT1; the disease is neoplasm.