Autophagy is believed to be positively correlated with the tumor occurrence and metastasis.[51] Autophagy has protumorigenic roles through promoting immune evasion in PDAC by degrading MHC‐I,[52] or suppressing antitumor immunity mediated by CD8+T cells.[53] Conversely, autophagy also achieves antitumorigenic effects, including maintenance of genomic stability, suppression of oxidative stress, and inhibition of NRF2 activation.[36] Under the KEGG enrichment analysis, we found and proved that ATG7 was the downstream target of lnc‐FSD2‐31:1 in vivo and in vitro. This evidence concerns the gene ATG7 and neoplasm.