Due to the critical roles of miRNAs in tumor progression, the therapeutic effect of miR‐4736 in vivo was validated.[37] The presence of miR‐4736 in mouse PDAC cell lines PANC‐02 and KPC (LSL‐KrasG12D/+, LSL‐Trp53R172H/+, Pdx‐1‐Cre) transgenic mouse pancreatic cancer tissue were validated (Figure S6A–C, Supporting Information). This evidence concerns the gene PDX1 and pancreatic neoplasm.