LncRNAs drive a constellation of phenotypes of cancer by acting on dysfunctional intrinsic cellular regulatory networks and intercellular communication to generate the tumor microenvironment.[38] LncRNAs can bind with targeted intracellular proteins to enhance the PDAC phenotypes.[6] Our previous study has demonstrated that MALAT1 interacts with HuR, which promotes PDAC proliferation and metastasis.[35a] Inversely, lncRNAs could also interact with proteins or miRNAs to inhibit the spread of complexes across different chromatin domains and affect different types of cells. This evidence concerns the gene MALAT1 and cancer.