PDPN and neoplasm: Interestingly, the expression levels of vimentin and podoplanin, which also are the markers of CAFs in PDAC, did not change under the same coculture conditions (Figure S2E,F, Supporting Information).[27] Since tumor cells can only make contacts with CAFs through micropores (less than 400 nm), we speculated that EVs may act as carriers to enable the communication between these two cell types.