EIF4E and cancer: Further, as the active concentration of translation initiation factors including eIF4F is (i) tightly controlled in cellular programmes like proliferation and differentiation (76–78), (ii) can vary between tissues and iii) is often dramatically affected in many different cancers (59,79–81), regulation and dysregulation of eIF4A1 multimer formation is likely to have a strong impact on the translational landscape of the cell.