UBE2A and Alzheimer disease: They reported that down-regulation of ciRS-7 in AD contributed to an up-regulation of miRNA-7 which in turn down-regulated an autophagic, phagocytic protein essential in the clearance of neurotoxic amyloid-beta (Aβ) peptides namely ubiquitin protein ligase A (UBE2A; Zhao et al., 2022).