Cerebral ischemia may lead to aggregation of neurodegeneration-related disease proteins including PSF/SFPQ, p54/NONO, TDP43, FUS, and hnRNPA1, all of which have been linked to neurodegeneration associated with frontotemporal dementia and amyotrophic lateral sclerosis (ALS; Kahl et al., 2018). Here, SFPQ is linked to brain ischemia.