Some of the regulatory roles of circRNAs in neurodegenerative diseases have been discussed in this manuscript (e.g., circHectd1-miR-142-TIPARP axis, ciRS-7-miR-7/UBE2A axis, circGLIS3/miR-203 axis, circSNCA/miR-7/SNCA axis, circzip-2/miR-60/SNCA axis, circHIPK2/miR124/2HG axis, circHIPK2/miR124/SIGMAR axis, circSAMD4A/miR-29c-3p AMPK/mTOR axis, circ016719/miR-29c/MAP2K6 axis, and circAKAP7/miR-155-5p/ATG12 axis etc.). Here, UBE2A is linked to neurodegenerative disease.