MXI1 and non-small cell lung carcinoma: Ubiquitin-conjugating enzyme E2O (UBE2O), an E2/E3 hybrid ubiquitin-protein ligase, targets MAX-interacting protein 1 (Mxi1) for ubiquitination and degradation at the K46 residue, which can suppress the occurrence of NSCLC and enhance radiosensitivity (82).