These genes included IDH1, tumor protein 53 (TP53), alpha-thalassemia/mental retardation, X-linked (ATRX); capicua transcriptional repressor (CIC), titin (TTN), epidermal growth factor receptor (EGFR), phosphatase and tensin homolog (PTEN), neurofibromin 1 (NF1), far upstream element-binding protein 1 (FUBP1), neurogenic locus notch homolog protein 1 (NOTCH1), filaggrin (FLG), ryanodine receptor 2 (RYR2), spectrin alpha, erythrocytic 1 (SPTA1); alpha-3 chain of type VI collagen (COL6A3), and low-density lipoprotein-related protein 2 (LRP2). This evidence concerns the gene FLG and Intellectual disability.