Such lower levels of H3K27me3 in PFA ependymomas are due to the overexpression of EZHIP (“enhancer of zeste homolog inhibitory protein”), a protein that might work as a potential tumor driver in PFA and that mimics K27M mutated histones, functioning as an intrinsic inhibitor of PRC2 function (35). This evidence concerns the gene EZHIP and ependymoma.