BRAF and central nervous system cancer: Particular interest has been focused on the presence of BRAF co-mutations: several cases (at least 15 to 20) of H3K27M/BRAFV600E double mutant gliomas have been described in many reports (mainly gangliogliomas, thalamic gliomas, and diffuse supratentorial gliomas), and sometimes such cases showed long survival (42, 51, 57–61).