It encompassed new sub-classification for diffuse gliomas, medulloblastomas, and other embryonal tumors, and it defined new entities based on their unique molecular features (glioblastoma, IDH-wild-type, and glioblastoma, IDH-mutant; diffuse midline glioma, H3K27M-mutant; RELA fusion-positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumor with multilayered rosettes, C19MC-altered) (2). The gene discussed is SHH; the disease is embryonal neoplasm.