Moreover its role in non-neoplastic categories like AD (Alzheimer disease) (32), PD (Parkinson disease) (33) and POF (premature ovarian failure) (34), where the dysregulation is associated with different pathological responses, FOXO3 is indispensably connected to cellular proliferation (35), apoptosis (36), progression in cell cycle (37, 38) and DNA damage (39). This evidence concerns the gene FOXO3 and primary ovarian failure.