Using the best lambda parameters in the 10-fold validations, we finally selected 12 hub autophagy-associated genes, including APOL1, BAG1, BAG3, BAX, CAPN10, DNAJB2, KLHL24, P4HB, RAC1, RAF1, SERPINA1, and SIRT1 (Figures 2A, B), which, as expected, were significantly differentially expressed in AML patients (Figure 2C). Here, SIRT1 is linked to acute myeloid leukemia.