BAG3 and acute myeloid leukemia: For instance, KLHL24 has a hazard ratio of less than 1 in AML patients and was regarded as a protective gene (HR=0.71, 95% CI=0.53-0.94, P=0.016, Figure 2D), while BAG3 was considered a risk gene (HR=1.23, 95% CI=1.08-1.40, P=0.002, Figure 2D).