have demonstrated that circGLIS3 (hsa_circ_0002874, originating from exon 2 of GLIS3) in exosomes promotes high-grade glioma invasion by regulating Ezrin phosphorylation (110).Wang Xu and colleagues have revealed that TDEs of glioblastoma (GBM) can fuse to the surface of T cells, increase the concentration of adenosine around T cells, activate adenosine receptor 2A (A2AR), and inhibit aerobic glycolysis in T cells, thereby suppressing T-cell clonal proliferation by reducing energy production. The gene discussed is ADORA2A; the disease is glioblastoma.