PvTRAP is immunogenic in natural infections since naturally acquired antibodies to recombinant PvTRAP were detected in exposed individuals from the Brazilian Amazon (100), Thailand (101), Iran (102), Afghanistan (102) and Pakistan (102).A positive correlation between the IgG3 response and longer times to the last malaria episode was found, suggesting that this subclass could be related to protection (100). This evidence concerns the gene IGHG3 and malaria.