From our observations, on the one hand, the NMO induction dramatically decreased the rhythm-regulating genes, including Bmal1 and Clock, which were increased by Cx43 activator LA and glutamate, suggesting that Cx43-glutamate signaling would be a critical upstream regulator that contributes to the NMO-induced rhythmic damage in SCN astrocytes. The gene discussed is GJA1; the disease is neuromyelitis optica.