EPG5 and Vici syndrome: Since the discovery of the autophagy-related gene (ATG) in 1990 and its role in cellular homeostasis, numerous other genetic mutations associated with impaired autophagy have been discovered, including BECN1 (breast and ovarian cancer), CLEC16A (diabetes and multiple sclerosis), CTNS (Cystinosis), EPG5 (Vici syndrome), and GBA1 (Gaucher’s disease).