Dysregulation of cytokine profiles has been proved and is frequently associated with an enhancement of proinflammatory cytokines (such as interleukin (IL)-1, IL-6, IL-8, and TNF-α) and attenuation of anti-inflammatory cytokines (such as IL-10 and TGF-β) in patients with RA (4). This evidence concerns the gene IL1B and rheumatoid arthritis.