IGFBP2 and central nervous system cancer: Most of these genes, including DBI (45), FYN (46), IL18 (47), CDK1 (48), RPS3 (49), PDCD1LG2 (50), FADD (51), CXCL12 (52), CLIC1 (53), CDK2 (54), IGFBP2 (55) and LRRC32 (56), have been reported to play critical roles in the development, stemness, and immunogenicity of gliomas.