Most of these genes, including DBI (45), FYN (46), IL18 (47), CDK1 (48), RPS3 (49), PDCD1LG2 (50), FADD (51), CXCL12 (52), CLIC1 (53), CDK2 (54), IGFBP2 (55) and LRRC32 (56), have been reported to play critical roles in the development, stemness, and immunogenicity of gliomas. The gene discussed is FADD; the disease is central nervous system cancer.