Thirteen factors that may affect CR were selected for univariate analysis, including gender, age, CEA level before neoadjuvant therapy, pre-T stage, pre-N stage, pre-M stage, distance from the lower edge of the tumor to the anus, neoadjuvant regimen, MRI-circumferential resection margin (CRM), degree of pathological differentiation before neoadjuvant therapy, death, and new distant metastasis. This evidence concerns the gene CEACAM5 and neoplasm.