In addition, Kuhl et al. found no significant difference in the diagnostic accuracy of bpMRI and mpMRI in repeated biopsies of 542 men with elevated PSA values (20, 21), which further suggested that the use of bpMRI with diagnostic specificity as an auxiliary modality for prostate cancer may be able to decrease unnecessary prostate biopsies. This evidence concerns the gene KLK3 and Familial prostate cancer.