Diabetes mellitus in general has many types, depending on the pathogenesis and the time of incidence, starting from the impaired secretion of insulin (type I) to impaired utilization of the produced insulin (type II), and the management approach differs in each patient according to the type, dosage, number of medication according to the type of DM, patient response, and caloric intake, along with other factors to be considered. Here, INS is linked to diabetes mellitus.