In a previous study, TSD was revealed to destroy the proapoptotic protein Bax expression, promote the antiapoptotic protein Bcl2 expression, reduce the lactate dehydrogenase exudation, increase the antioxidant enzyme superoxide dismutase activity, and decrease the lipid oxide malondialdehyde content in ischemic Sprague-Dawley rat model through resisting cell oxidation and apoptosis, indicating a potential protective effect on VaD [12]. The gene discussed is BCL2; the disease is Tay-Sachs disease.