CXCL8 interacts with CXCL1 and CXCL2 to promote the secretion of multiple proinflammatory, angiogenic, and immunomodulatory factors (including MMP and VEGF) by neutrophils, thereby promoting tumor metastasis in patients with NSCLC [36, 37]. The gene discussed is CXCL2; the disease is neoplasm.