CXCL8 interacts with CXCL1 and CXCL2 to promote the secretion of multiple proinflammatory, angiogenic, and immunomodulatory factors (including MMP and VEGF) by neutrophils, thereby promoting tumor metastasis in patients with NSCLC [36, 37]. This evidence concerns the gene CXCL1 and neoplasm.