The results showed the highest enrichment in tumor-related signaling pathway (target number 15), lipid and atherosclerosis signaling pathway (target number 10), PI3K-Akt signaling pathway (target number 10), and neurodegenerative signaling pathway (target number 10), indicating that Citrus aurantium can treat NSCLC through these pathways. This evidence concerns the gene AKT1 and atherosclerosis.