It also demonstrated anti-tumor activity on CRC cells by inhibiting human CRC cell proliferation, inducing endoplasmic reticulum stress, modulating the G2/M phase of cell cycle progression, and inducing reactive oxygen species-mediated apoptosis through c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinases (MAPK) (31). Here, MAPK8 is linked to colorectal carcinoma.