In addition, further by observing the degree of lipid accumulation and detecting the expression of liver kinase B1 (LKB1)-adenosine 5′-monophosphate-activated protein kinase (AMPK) pathway-related proteins in HLP model mice liver, it was found that the possible action mechanism of promoting lipid metabolisms is the activation of AMPKα protein phosphorylation (64). Here, STK11 is linked to hyperkeratosis lenticularis perstans.