MRC1 and neoplasm: Macrophages which reside in the tumor, referred to as tumor associated macrophages (TAMs), are a highly plastic stromal cell type which facilitate cancer progression (DeNardo et al., 2009; Murray et al., 2014; Mantovani et al., 2017; Muliaditan et al., 2018; Opzoomer et al., 2021) and express DC-SIGN (Amin et al., 2015) and MMR within the tumor microenvironment.