INPP5D and Alzheimer disease: Additional examples of high-impact SNPs identified in AD include rs10933431 overlapping an intron of INPP5D (PIP = 46.4%, ATAC allelic imbalance P-value = 5.81*10−6) and rs7920721 upstream of USP6NL (PIP = 14.2%, ATAC allelic imbalance P-value = 4.92*10−5; Supplementary Fig. S6).